Game developer Bethesda has a history of making great games. But there's a darker side to their efforts: all of their games are buggy as hell. Of course, that's never stopped them from inflicting their work on the public.
Fallout 4 is no exception to this historical pattern. The game can be a lot of fun to play, when it works. But play it long enough on a PC, and there's a good chance that you'll start to experience the dreaded 'infinite load screen'.
Fallout 4 sees every transition as an opportunity to annoy you with load screens that take forever, or just a really long time (so long that you eventually give up, anyway). Transitions (and the chance of an infinite load screen) occur when you fast travel, and when you enter and exit indoor locations (so basically, all the time). There's no way to know whether the load screen you're staring at will ever end; at some point it just seems like killing the process and restarting the game is going to be less aggravating than continuing to wait.
If you search the web for 'fallout 4 infinite load screens', you'll find something else seemingly infinite: people complaining about this problem. What you won't find is anything resembling help from Bethesda. There are lots of suggestions from other players, but sadly, none of them worked for me. And I've tried them all.
I'm giving up on Fallout 4. Bethesda may fix this problem some day, but I'm not holding my breath. And even if they do, I won't soon be able to face that loading screen, no matter how briefly it appears.
Recommendation: avoid Fallout 4 unless you enjoy frustration.
For your viewing annoyance, I've posted a video on YouTube that demonstrates this fun feature.